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Effects of coffee intake and intraperitoneal caffeine on bone repair process - a histologic and histometric study

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dc.contributor.author Macedo, Rander Moreira
dc.contributor.author Brentegani, Luiz Guilherme
dc.contributor.author Lacerda, Suzie Aparecida de
dc.date.accessioned 2022-06-30T18:24:53Z
dc.date.available 2022-06-30T18:24:53Z
dc.date.issued 2015
dc.identifier.citation MACEDO, R. M.; BRENTEGANI, L. G.; LACERDA, S. A. Effects of coffee intake and intraperitoneal caffeine on bone repair process - a histologic and histometric study. Brazilian Dental Journal, Ribeirão Preto, v. 26, n. 2, p. 175-180, mar./abr. 2015. pt_BR
dc.identifier.issn 1806-4760
dc.identifier.uri https://doi.org/10.1590/0103-6440201300219 pt_BR
dc.identifier.uri http://www.sbicafe.ufv.br/handle/123456789/13564
dc.description.abstract Studies have suggested that caffeine acts on bone promoting an increase of calcium excretion, inhibition of osteoblast proliferation and delay in tissue repair process, raising the risk of fractures, osteoporosis, periodontal disease and affecting the success of bone reconstructive procedures. The aim of this study was to analyze histomorphometrically the process of alveolar bone healing after tooth extraction in rats subjected to daily intake of boiled coffee or intraperitoneal administration of caffeine. Forty-five male rats were divided according to the treatment in Control group (C); Coffee group (CO) - treated with coffee since birth; and Caffeine (CAF) - intraperitoneal injection of aqueous solution of caffeine 1.5% (0.2 mL/100g body weight) for 30 days. When weighing between 250-300 g they were anesthetized, subjected to extraction of the maxillary right incisor, and euthanized 7, 21 and 42 days after surgery for histological assessments of bone volume and the quality of formed bone in the dental socket. The qualitative results demonstrated larger amounts of blood clot and immature bone in animals under treatment of pure caffeine compared to coffee and control. Histometric analysis revealed that coffee treatment led to a 40% drop in bone formation, and caffeine a 60% drop in comparison to control animals (ANOVA p≤0.01). It was concluded that both the daily ingestion of coffee and the intraperitoneal administration of caffeine in rats delayed the alveolar bone reparative process after tooth extraction, and this effect was more aggressive when pure caffeine was used. pt_BR
dc.format pdf pt_BR
dc.language.iso en pt_BR
dc.publisher Fundação Odontológica de Ribeirão Preto pt_BR
dc.relation.ispartofseries Brazilian Dental Journal;v.26, n.2, 2015
dc.rights Open Access pt_BR
dc.subject Caffeine pt_BR
dc.subject Bone repair pt_BR
dc.subject Dental socket pt_BR
dc.subject Histomorphometry pt_BR
dc.subject.classification Cafeicultura::Café e saúde pt_BR
dc.title Effects of coffee intake and intraperitoneal caffeine on bone repair process - a histologic and histometric study pt_BR
dc.type Artigo pt_BR

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